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September 10, 2025Nutrition Metabolism and Cardiovascular DiseasesOpen Access

Development and Validation of a Phase-Sensitive Bioelectrical Equation for Estimating Skeletal Muscle Mass Using DXA as Reference

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Authors

FCFrancesco CampaASAlessandro SampieriGSGioi Spinello

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Overview

This analysis demonstrates a new equation for estimating skeletal muscle mass using BIA and DXA, indicating improved accuracy over previous methods.

Key Points

  • The new predictive equation estimates skeletal muscle mass with a high accuracy, indicating a coefficient of determination (R2) of 0.88.
  • Using data from 228 men and 125 women, the equation incorporates bioelectrical factors such as sex, phase angle, and reactance.
  • Agreement analysis shows that the new equation has no significant bias compared to the overall skeletal muscle mass assessed with DXA.
  • Lin's concordance correlation coefficient suggests that the new model offers better accuracy than the previously established Janssen equation.

Cite This Study

Campa et al. (2025) studied this question.

synapsesocial.com/papers/68c1cc4754b1d3bfb60f4e44https://doi.org/10.1016/j.numecd.2025.104281
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Development and validation of a new anthropometric equation to predict skeletal muscle mass in a heterogeneous Caucasian population2024
  2. 2Toward Clinically Feasible Assessment of Muscle Mass: Validation of a Seated Bioelectrical Impedance Device Against Dual-Energy X-Ray Absorptiometry (DXA) in Older Adults2026
  3. 3Assessing skeletal muscle mass and lean body mass: an analysis of the agreement among dual X-ray absorptiometry, anthropometry, and bioelectrical impedance2024 · 28 citations
  4. 4Population‐Based Prediction Equations for Appendicular Skeletal Muscle Mass: A Three‐Phase Validation Study in 13 582 Asian Adults2026
  5. 5A potential bioelectrical impedance equation for estimating skeletal muscle area using computed tomography in colorectal cancer2025