Key result
Left bundle branch area pacing improves LVEF by ~11% in patients with mildly reduced heart failure.
Why the study?
Cardiac resynchronization therapy for HFmrEF remains controversial, and the impact of left bundle branch area pacing as an alternative pacing modality in this population was unclear.
Does left bundle branch area pacing improve LVEF and reduce QRS duration in patients with heart failure with mildly reduced ejection fraction?
Population
211 mid-range heart failure patients with LVEF between 35% and 50% across 16 centers
Comparison
LBBAP at follow-up vs baseline
Design
Systematic literature review and meta-analysis of 8 articles
Follow-up
Average 9.1 months
Authors
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May support LBBAP as CRT option in HFmrEF; extends pacing evidence to this understudied group.
Meta-Analysis (n=211)
Yes
Does left bundle branch area pacing improve LVEF and reduce QRS duration in patients with heart failure with mildly reduced ejection fraction?
Effect estimate: MD 10.90% (95% CI 6.56-15.23)
Absolute Event Rate: 50.5% vs 39.8%
p-value: p=<.01
LBBAP significantly reduces QRS duration and improves systolic function in patients with HFmrEF, suggesting it may be a viable CRT strategy for this population.
Yu et al. (2023) conducted a meta-analysis in Heart failure with mildly reduced ejection fraction (HFmrEF) (n=211). Left bundle branch area pacing (LBBAP) vs. Baseline was evaluated on Left ventricular ejection fraction (LVEF) (MD 10.90%, 95% CI 6.56-15.23, p=<.01). Left bundle branch area pacing significantly improved LVEF from 39.8% to 50.5% (MD 10.90%; 95% CI 6.56-15.23; p<.01) in patients with mildly reduced heart failure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: