Hepatocellular Carcinoma with Peritoneal Dissemination which was Regressed during Vitamin K2 and Vitamin E Administration

Toshiyuki Otsuka; Satoshi Hagiwara; Hiroki Tojima; Hiroaki Yoshida; Tetsushi Takahashi; Kazumi NAGASAKA; Shinichi Tomioka; Tetsu Ando; Kunio Takeuchi; Takayuki Kori; Yoshihiro Ohno; Satoru Kakizaki; Hitoshi Takagi; Masatomo Mori

doi:10.2169/internalmedicine.46.6131

January 1, 2007Internal MedicineOpen Access

Hepatocellular Carcinoma with Peritoneal Dissemination which was Regressed during Vitamin K2 and Vitamin E Administration

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Key Points

To describe the regression of peritoneal dissemination in a patient with ruptured hepatocellular carcinoma treated conservatively with vitamin K2 and vitamin E.
A 65-year-old male with chronic renal failure and anti-HCV antibodies presented with ruptured hepatocellular carcinoma diagnosed via computed tomography.
The patient received two sessions of transcatheter arterial embolization followed by exploratory surgery identifying peritoneal seeding, after which conservative treatment with oral vitamins K2 and E was initiated.
Tumor response and peritoneal dissemination were tracked via follow-up computed tomography scans and serum alpha-fetoprotein monitoring.
Six months after initiating vitamin K2 and vitamin E, computed tomography revealed that intraperitoneal dissemination had completely disappeared.
The primary hepatocellular carcinoma tumor remained stable and did not increase in size during the six-month follow-up period.

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Implication

Case report demonstrates peritoneal dissemination regression in a patient with hepatocellular carcinoma receiving vitamins K2 and E, suggesting potential tumor-suppressive effects of combination...

Abstract

A 65-year-old man with positive anti-hepatitis C antibody and chronic renal failure was diagnosed as having a ruptured hepatocellular carcinoma (HCC) based on computed tomography (CT). The patient underwent transcatheter arterial embolization (TAE) for the HCC. After one more session of TAE, the patient underwent surgery. But HCC seeding peritoneally was pointed out. Vitamin K2 and vitamin E were administered as a conservative treatment. Six months after starting vitamins K2 and E, the primary tumor did not increase in size and intraperitoneal dissemination disappeared on CT with a significant decrease of alpha-fetoprotein. Even though this is only one case, combination therapy of vitamin K2 and E may induce growth suppression of HCC.

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Otsuka et al. (2007) studied this question.

synapsesocial.com/papers/6a0b5169db419d24cd5d02dc https://doi.org/10.2169/internalmedicine.46.6131

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Hepatocellular Carcinoma with Peritoneal Dissemination which was Regressed during Vitamin K2 and Vitamin E Administration

Key Points

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Cite This Study

Hepatocellular Carcinoma with Peritoneal Dissemination which was Regressed during Vitamin K2 and Vitamin E Administration

Key Points

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Implication

Abstract

Discussion

Cite This Study

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