Stage 1 and stage 2 hypertension were highly prevalent among Chinese adults, and higher blood pressure grades were associated with an increased risk of developing diabetes.
Cohort (n=32,625)
Yes
Does stage 1 and stage 2 hypertension increase the risk of developing diabetes in adults free of diabetes at baseline?
Both stage 1 and stage 2 hypertension are associated with an increased risk of developing diabetes, emphasizing the need for early blood pressure management.
Hypertension is a common and serious public health issue, with elevated blood pressure significantly increasing the risk of cardiovascular disease and diabetes. In adults, blood pressure values of 130–139 mm Hg/80–89 mm Hg are associated with an increasing relative risk of cardiovascular complications and mortality. According to the American College of Cardiology (ACC) / American Heart Association (AHA) criteria for the diagnosis of hypertension, this study aimed to describe the prevalence and risk factors for stage 1 (systolic blood pressure 130–139 mm Hg or diastolic blood pressure 80–89 mm Hg) and stage 2 (systolic blood pressure ≥ 140 mm Hg or diastolic blood pressure ≥ 90 mm Hg) hypertension. Second, to evaluate the effect of different hypertension grades on the incidence of diabetes. Data were obtained from the DATADRYAD database. This study included 32,625 adults from 32 regions in 11 cities in China, enrolled between 2010 and 2016, who were free of diabetes at baseline. Logistic regression was used to assess the risk factors for different grades of hypertension. Cox proportional hazard regression analysis was performed to explore the relationship between stage 1 and stage 2 of hypertension and diabetes. All data were analyzed using the SAS 9.4 software and R software (version 4.2.2). The study showed that the prevalence of stage 1 and stage 2 hypertension was higher, and the prevalence of stage 1 was higher than stage 2 hypertension. Sex, age, body mass index (BMI), fasting plasma glucose, triglycerides, and alanine aminotransferase (ALT) were the risk factors for stage 1 hypertension, and sex, age, BMI, cholesterol, triglycerides, ALT, and alcohol drinking were risk factors for stage 2 hypertension. In addition, our study demonstrated a significant interaction between age and sex, BMI and sex on the risk of hypertension, respectively. Furthermore, the higher the blood pressure, the higher the risk of developing diabetes. These findings highlight the importance of paying attention not only to individuals with stage 2 hypertension but also to those with stage 1 hypertension, given the elevated risk of diabetes associated with both.
Jia et al. (Sat,) conducted a cohort in Hypertension (n=32,625). Stage 1 and Stage 2 hypertension vs. Lower blood pressure grades was evaluated on Prevalence of hypertension and incidence of diabetes. Stage 1 and stage 2 hypertension were highly prevalent among Chinese adults, and higher blood pressure grades were associated with an increased risk of developing diabetes.
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