Key result
Lowering diastolic blood pressure below a critical level is associated with an increase in adverse cardiovascular events, a phenomenon known as the diastolic J curve.
Why the study?
Does lowering diastolic blood pressure below a critical level increase adverse cardiovascular events in hypertensive patients?
Does lowering diastolic blood pressure below a critical level increase adverse cardiovascular events in hypertensive patients?
The existence of a diastolic J curve suggests that excessive lowering of diastolic blood pressure, particularly in elderly patients with isolated systolic hypertension, may increase cardiovascular events.
May support caution with aggressive diastolic lowering in isolated systolic hypertension; leaves open optimal targets for randomized trials.
The occurrence of additional cardiovascular events when the diastolic blood pressure is lowered below a critical level is referred to as "the diastolic J curve." Although the critical level of diastolic blood pressure where the J curve begins is not certain, increasingly strong evidence from prospective, controlled studies has confirmed the existence of such a J curve. With the likely addition of more patients who will be treated more vigorously, in particular, elderly subjects with isolated systolic hypertension, the potential for an increase in the number of adverse cardiovascular events must be considered and caution used to avoid too low a diastolic blood pressure.
No takes yet. Share an insight, caveat, or question.
Norman M. Kaplan (2011) conducted a review in Hypertension. Lowering diastolic blood pressure was evaluated on Cardiovascular events. Lowering diastolic blood pressure below a critical level is associated with an increase in adverse cardiovascular events, a phenomenon known as the diastolic J curve.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: