Efficacy of azilsartan on left ventricular diastolic dysfunction compared with candesartan: J-TASTE randomized controlled trial

Figures

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  Figure 1. The study flow chart for the enrollment, randomization, and follow-up. The participants who did not receive a dose of either azilsartan or candesartan were excluded from the primary and safety analyses. Both FAS and SAF denotes full analysis set and safety analysis set, respectively.

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  Figure 2. The changes in the parameters of left ventricular diastolic function with echocardiography from baseline to 48 weeks. (A) E/e′ ratio obtained from the averaged the values of septal and lateral e′, (B) e′ velocity obtained from the averaged values of septal and lateral e′, (C) E/A ratio and (D) the deceleration time of early diastolic mitral annular velocity. The statistical analyses of absolute changes in E/e′ from baseline to 48 weeks were performed using analysis of covariance adjusted for the baseline data. The absolute change in e′, E/A ratio and deceleration time from baseline to 48 weeks between the groups were compared using Student’s t test. Data are expressed as mean ± 95% confidence interval. E/e′ the ratio of peak early diastolic transmitral flow velocity (E) to early diastolic mitral annular velocity (e′), E/A ratio the ratio of peak early diastolic transmitral flow velocity (E) to atrial systolic transmitral flow velocity (A).

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  Figure 3. The changes in E/e′ from baseline to 48 weeks stratified by the potential influential factors. The statistical analyses of absolute changes in each parameter from baseline to 48 weeks were performed using analysis of covariance adjusted for the baseline data. LSM, 95% CI and p values were calculated from the analysis of covariance model. The LSM difference (3.0 ± 0.5, 95% CI − 8.34 to 14.21) in the patients with LVEF < 50% was omitted because the 95% CI was large due to small sample size. BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, E/e′ ratio the peak early diastolic transmitral flow velocity (E) to peak early diastolic mitral annulus velocity (e′), eGFR estimated glomerular filtration rate, NYHA New York Heart Association, LVEF left ventricular ejection fraction, LSM least-squares mean, CI confidence interval.

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  Figure 4. The changes in systolic (A) and diastolic (B) blood pressure at each study visit. Data are expressed as mean ± standard deviation. SBP systolic blood pressure, DBP diastolic blood pressure.