Key result
Azilsartan significantly reduced sitting diastolic blood pressure by an additional 2.6 mm Hg compared to candesartan at 16 weeks in Japanese patients with grade I-II essential hypertension.
Why the study?
Does azilsartan reduce blood pressure more effectively than candesartan in Japanese patients with grade I-II essential hypertension?
Population
622 Japanese adults with grade I-II essential hypertension. Excluded: grade III hypertension, secondary or…
Comparison
Azilsartan 20-40 mg oral once daily by forced… vs Candesartan cilexetil 8-12 mg oral once daily by…
Design
RCT, Randomized equally via an interactive web response system using plasma…
Follow-up
16 weeks
Authors
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Supports azilsartan over candesartan for greater diastolic BP reduction in Japanese grade I-II hypertension; extends comparative ARB efficacy data.
RCT (n=622)
Double-blind
Stratified randomization
Yes
Does azilsartan reduce blood pressure more effectively than candesartan in Japanese patients with grade I-II essential hypertension?
Mean Difference: -2.6 (95% CI -4.08–-1.22)
Absolute Event Rate: -12.4% vs -9.8%
p-value: p=0.0003
Azilsartan 20-40 mg once daily provides a significantly greater and more sustained 24-hour blood pressure reduction compared to candesartan 8-12 mg in Japanese patients with grade I-II essential hypertension.
Rakugi et al. (2012) conducted an RCT in Grade I-II essential hypertension (n=622). Azilsartan vs. Candesartan cilexetil 8-12 mg once daily was evaluated on Mean change from baseline in sitting trough diastolic blood pressure at week 16 (MD -2.6 mm Hg, 95% CI -4.08 to -1.22, p=0.0003). Azilsartan significantly reduced sitting diastolic blood pressure by an additional 2.6 mm Hg compared to candesartan at 16 weeks in Japanese patients with grade I-II essential hypertension.
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