Key result
Aminoguanidine treatment prevented AVF-induced increases in left ventricular longitudinal stiffness and septal circumferential stiffness by reducing AGE collagen cross-linking in rats.
Why the study?
Does aminoguanidine prevent changes in myocardial diastolic mechanics and stiffness in rats with volume-overload hypertrophy?
Population
Rats with volume overload induced by arteriovenous fistula (AVF)
Comparison
Aminoguanidine (AG) vs Rats with volume overload induced by AVF not…
Design
Preclinical
Authors
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Should not yet change clinical practice in volume overload; leaves open whether AGE inhibition improves diastolic compliance in humans.
Does aminoguanidine prevent changes in myocardial diastolic mechanics and stiffness in rats with volume-overload hypertrophy?
Aminoguanidine prevents increases in AGE collagen cross-linking and myocardial stiffness in a rat model of volume-overload hypertrophy, suggesting AGE cross-linking mediates diastolic compliance.
Herrmann et al. (2003) studied Volume-overload hypertrophy. Aminoguanidine (AG) vs. AVF without AG was evaluated on Myocardial diastolic mechanics, stiffness, and AGE collagen cross-linking. Aminoguanidine treatment prevented AVF-induced increases in left ventricular longitudinal stiffness and septal circumferential stiffness by reducing AGE collagen cross-linking in rats.
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