Key result
Tocainide 1200 mg combined with metoprolol 200 mg significantly reduced the modified Lown score compared to placebo (32 vs 53, p<0.01) and was superior to single drug therapy for stable PVCs.
Why the study?
Does the combination of tocainide and metoprolol reduce premature ventricular contractions in patients with stable PVCs compared to placebo or monotherapy?
Population
20 patients with premature ventricular contractions class Lown ≥ 2 judged as being 'stable' by at least…
Comparison
Tocainide 1800 mg/day or metoprolol 200 mg/day… vs Placebo period and single drug therapy.
Design
RCT, randomized to therapy, double-blind
Follow-up
15 days per treatment period
Authors
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May warrant combination tocainide-metoprolol for stable PVCs; confirms additive benefit over monotherapy in this RCT.
RCT (n=20)
Double-blind
Randomized crossover
Does the combination of tocainide and metoprolol reduce premature ventricular contractions in patients with stable PVCs compared to placebo or monotherapy?
Absolute Event Rate: 32% vs 53%
p-value: p=<0.01
The combination of tocainide 1200 mg and metoprolol 200 mg is well tolerated and superior to single drug therapy in reducing stable premature ventricular contractions.
Capucci et al. (1989) conducted an RCT in Premature ventricular contractions (PVCs) (n=20). Tocainide and metoprolol vs. Placebo and single drug therapy was evaluated on Modified Lown score (p=<0.01). Tocainide 1200 mg combined with metoprolol 200 mg significantly reduced the modified Lown score compared to placebo (32 vs 53, p<0.01) and was superior to single drug therapy for stable PVCs.
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