Key result
Long-term clozapine linked to neuroleptic malignant syndrome presenting with acute renal failure and pulmonary edema.
Clozapine use can be associated with neuroleptic malignant syndrome leading to severe complications like acute renal failure and pulmonary edema.
Clozapine may rarely trigger severe NMS with renal failure and pulmonary edema; single case leaves open monitoring and prevention strategies.
Neuroleptic malignant syndrome is a rare, but potentially life-threatening adverse event associated with the use of neuroleptic agents. We describe the case of a 47-year-old schizophrenic woman who was treated with clozapine for years. The patient developed acute renal failure with pulmonary edema, and underwent mechanical ventilation and hemodialysis.
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Jo et al. (2016) studied this question. Long-term clozapine treatment induced neuroleptic malignant syndrome presenting with acute renal failure and pulmonary edema that required mechanical ventilation and hemodialysis.
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