Key result
Clozapine monotherapy is linked to six cases of neuroleptic malignant syndrome despite weak dopamine affinity.
Clozapine monotherapy can precipitate neuroleptic malignant syndrome, challenging the assumption that its weak dopamine receptor affinity would prevent this complication.
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Clozapine may still precipitate neuroleptic malignant syndrome; case reports leave mechanisms beyond dopamine affinity open for prospective study.
Thornberg et al. (1993) conducted a review in Neuroleptic malignant syndrome (n=6). Clozapine monotherapy was evaluated on Neuroleptic malignant syndrome. Six cases of neuroleptic malignant syndrome have been reported in patients receiving clozapine monotherapy, despite its weak affinity for dopamine receptors.
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