October 1, 1995Journal of Clinical Psychopharmacology
Clozapine-Induced Neuroleptic Malignant Syndrome
Why the study?
Does clozapine induce neuroleptic malignant syndrome and what are its clinical features?
Population
Patients exposed to clozapine, including an estimated 1,250 patients in Australia and previously published…
Comparison
Clozapine vs Classic neuroleptics (historical comparison)
Design
Review
Authors
Discussion
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Implication
Vigilance for atypical NMS remains essential with clozapine; leaves open comparative incidence and management in prospective studies.
Structured PICO
Does clozapine induce neuroleptic malignant syndrome and what are its clinical features?
P
Population
Patients exposed to clozapine, including an estimated 1,250 patients in Australia and previously published case reports.
I
Intervention
Clozapine
C
Comparator
Classic neuroleptics (historical comparison)
O
Outcome
Incidence and clinical features of neuroleptic malignant syndrome (NMS)safety
Clozapine can induce neuroleptic malignant syndrome, which may present atypically with fewer extrapyramidal symptoms and lower creatine kinase elevations compared to classic neuroleptics.
Cite This Study
Sachdev et al. (1995) studied this question.