Key result
In a patient with Brugada syndrome, the appearance of J waves, rather than ST-segment elevation, was characteristic before the onset of ventricular fibrillation.
Case Report (n=1)
In a patient with Brugada syndrome, J waves appeared characteristically before ventricular fibrillation, suggesting a mechanism involving heterogeneous distribution of the refractory period due to K+ channel changes.
May herald imminent VF in Brugada syndrome; hypothesis-generating case observation that leaves open prospective validation.
We describe a patient with Brugada syndrome. The ST-segment elevation in precordial leads was revealed during admission, but the appearance of J waves was characteristic before ventricular fibrillation (VF), rather than ST-segment elevation. J waves have been reported to be associated with the presence of an Ito-mediated prominent action potential notch in the epicardium. It is considered that one of the mechanisms of this VF is due to heterogeneous distribution of the refractory period according to changes in K+ channels including Ito.
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Daimon et al. (2000) conducted a case report in Brugada syndrome (n=1). In a patient with Brugada syndrome, the appearance of J waves, rather than ST-segment elevation, was characteristic before the onset of ventricular fibrillation.
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