What is the clinical evidence from this study?

Study design: Cohort. Population: chronic heart failure (n=175). Intervention: Peak circulatory power vs. Other cardiopulmonary exercise test variables. Primary outcome: Prognosis (survival) (p=<0.001).

What does this research mean for the field?

Peak circulatory power at peak exercise is a powerful independent predictor of prognosis in patients with chronic heart failure. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess the prognostic value of peak circulatory power, a non-invasive surrogate of cardiac power, in patients with chronic heart failure.

May 15, 2002European Heart JournalOpen Access

A non-invasively determined surrogate of cardiac power ('circulatory power') at peak exercise is a powerful prognostic factor in chronic heart failure

Q: What are the key findings of this study?

Peak circulatory power at peak exercise was the only independent predictor of prognosis in patients with chronic heart failure (chi-square=19.9, P<0.001).

Q: What does this research mean for the field?

Peak circulatory power at peak exercise is a powerful independent predictor of prognosis in patients with chronic heart failure. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

To assess the prognostic value of peak circulatory power, a non-invasive surrogate of cardiac power, in patients with chronic heart failure.

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Key result

Peak circulatory power independently predicts survival in chronic heart failure.

P<0.001
n=175

Why the study?

Peak exercise cardiac power and stroke work have proven prognostic value, but whether they offer better prognostic value than peak oxygen uptake was unclear.

Does non-invasively determined peak circulatory power predict prognosis in patients with chronic heart failure?

Key Points

To assess the prognostic value of peak circulatory power, a non-invasive surrogate of cardiac power, in patients with chronic heart failure.
Enrolled 175 patients with chronic heart failure (ejection fraction <45%) who completed a cardiopulmonary exercise test.
Calculated circulatory power as the product of systolic arterial pressure and peak oxygen uptake (VO2), and circulatory stroke work as the product of systolic arterial pressure and oxygen pulse.
Evaluated survival over a mean follow-up of 25±10 months using Kaplan-Meier analyses and univariate and multivariate Cox proportional hazards models.
Univariate analysis demonstrated that ejection fraction, heart rate, systolic arterial pressure, peak VO2, circulatory stroke work, and circulatory power predicted patient outcome.
Multivariate Cox analysis revealed that peak circulatory power was the only independent predictor of prognosis (chi-square=19.9, P<0.001), whereas peak circulatory stroke work was not predictive.

Study Design

Type

Cohort (n=175)

Structured PICO

Does non-invasively determined peak circulatory power predict prognosis in patients with chronic heart failure?

Population

175 patients with chronic heart failure (ejection fraction <45%)

Intervention

Non-invasive determination of peak circulatory power (product of systolic arterial pressure and peak VO2) during cardiopulmonary exercise testing

Outcome

Prognosis/outcome (assessed by survival curves)

Main Result

p-value: p=<0.001

Non-invasively measured peak circulatory power during cardiopulmonary exercise testing is a strong, independent predictor of outcomes in patients with chronic heart failure.

Discussion

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Implication

May refine prognostication in chronic heart failure; leaves open prospective validation before clinical adoption.

Cite This Study

Alain Cohen‐Solal (2002) conducted a cohort in chronic heart failure (n=175). Peak circulatory power vs. Other cardiopulmonary exercise test variables was evaluated on Prognosis (survival) (p=<0.001). Peak circulatory power at peak exercise was the only independent predictor of prognosis in patients with chronic heart failure (chi-square=19.9, P<0.001).

synapsesocial.com/papers/6a0baa0c4f6759c6fca256ef https://doi.org/10.1053/euhj.2001.2966

Topics

HFrEF treatment Heart transplantation Heart failure

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A non-invasively determined surrogate of cardiac power ('circulatory power') at peak exercise is a powerful prognostic factor in chronic heart failure

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Topics

A non-invasively determined surrogate of cardiac power ('circulatory power') at peak exercise is a powerful prognostic factor in chronic heart failure

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider