Key result
Metabolically benign overweight/obese women had significantly higher odds of elevated epicardial fat compared to normal weight women (OR 5.17; 95% CI 3.22-8.29), suggesting a transient state.
Why the study?
Do metabolically benign overweight/obese women have higher levels of ectopic fat and adverse adipokine profiles compared to normal weight women?
Population
Women screened for the Kronos Early Estrogen Prevention Study, categorized into metabolically benign…
Design
Cross-sectional
Authors
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May signal hidden CV risk in metabolically benign obesity; hypothesis-generating for prospective validation in women.
Cross-Sectional
Do metabolically benign overweight/obese women have higher levels of ectopic fat and adverse adipokine profiles compared to normal weight women?
Effect estimate: OR 5.17 (95% CI 3.22-8.29)
Metabolically benign overweight/obese women have significantly higher ectopic fat and adverse adipokine profiles compared to normal weight women, suggesting the 'metabolically benign' phenotype may be a transient state with elevated cardiovascular risk.
Ogorodnikova et al. (2013) conducted a cross-sectional in Overweight/Obesity. Metabolically benign overweight/obese (MBO) phenotype vs. Metabolically benign normal weight (MBNW) phenotype was evaluated on Top tertile of epicardial fat (OR 5.17, 95% CI 3.22-8.29). Metabolically benign overweight/obese women had significantly higher odds of elevated epicardial fat compared to normal weight women (OR 5.17; 95% CI 3.22-8.29), suggesting a transient state.
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