Key result
At-risk normal-weight women had higher odds of top-tertile leptin (OR 2.51; 95% CI 1.28-5.01) and bottom-tertile adiponectin compared to metabolically benign normal-weight women.
Population
1,993 postmenopausal women enrolled in a nested case-control stroke study ancillary to the Women's Health…
Design
Cross-sectional
Authors
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Adipokine profiles may distinguish at-risk from benign normal-weight phenotypes; leaves open causal role and prospective validation.
Cross-Sectional (n=1,993)
Effect estimate: OR 2.51 (95% CI 1.28-5.01)
Adiponectin levels are independent of BMI and may play a key role in the etiological pathway differentiating metabolically benign and at-risk phenotypes in postmenopausal women.
Khan et al. (2013) conducted a cross-sectional in Obesity and metabolic risk phenotypes (n=1,993). At-risk phenotype vs. Metabolically benign phenotype was evaluated on Leptin in the top tertile (at-risk vs metabolically benign normal-weight women) (OR 2.51, 95% CI 1.28-5.01). At-risk normal-weight women had higher odds of top-tertile leptin (OR 2.51; 95% CI 1.28-5.01) and bottom-tertile adiponectin compared to metabolically benign normal-weight women.
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