Body Size Phenotypes and Inflammation in the Women's Health Initiative Observational Study
Why the study?
Do overweight or obese postmenopausal women without clustering of cardiometabolic risk factors have abnormal levels of inflammatory markers compared to normal weight women?
Population
1,889 postmenopausal women from the Women's Health Initiative Observational Study nested case-control stroke…
Comparison
Overweight/obesity with 0 or 1 metabolic… vs Normal weight women with 0 or 1 metabolic…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
May signal persistent inflammation in metabolically healthy overweight postmenopausal women; hypothesis-generating and requires prospective validation before clinical implications.
Structured PICO
Do overweight or obese postmenopausal women without clustering of cardiometabolic risk factors have abnormal levels of inflammatory markers compared to normal weight women?
P
Population
1,889 postmenopausal women from the Women's Health Initiative Observational Study (WHI-OS) nested case-control stroke study
I
Intervention
Overweight/obesity with 0 or 1 metabolic syndrome components/diabetes, normal weight with ≥2 metabolic syndrome components/diabetes, and overweight/obesity with ≥2 metabolic syndrome components/diabetes
C
Comparator
Normal weight women with 0 or 1 metabolic syndrome components
O
Outcome
Having ≥3 inflammatory markers (acute-phase reactants, adhesion molecules, and coagulation products) in the top quartilesurrogate
Overweight or obese postmenopausal women without clustered cardiometabolic risk factors still exhibit heightened levels of inflammatory markers, challenging the concept of completely 'metabolically benign' obesity.
Cite This Study
Wildman et al. (2011) studied this question.