Key result
Metabolically healthy but obese postmenopausal women had significantly lower levels of C-reactive protein and alpha-1 antitrypsin compared to insulin-resistant obese women (P<0.05).
Why the study?
Do metabolically healthy but obese postmenopausal women have a more favorable inflammatory profile compared to insulin-resistant obese women?
Cross-Sectional (n=88)
Do metabolically healthy but obese postmenopausal women have a more favorable inflammatory profile compared to insulin-resistant obese women?
p-value: p=< 0.05
Metabolically healthy but obese postmenopausal women exhibit a favorable inflammatory profile with lower CRP and alpha-1 antitrypsin levels compared to insulin-resistant obese women, potentially explaining their lower cardiovascular risk.
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Suggests lower inflammation may underlie reduced cardiovascular risk; leaves open causal validation in prospective postmenopausal studies.
Karelis et al. (2005) conducted a cross-sectional in Obesity (n=88). Metabolically healthy but obese (MHO) phenotype vs. Insulin-resistant 'at risk' obese phenotype was evaluated on Inflammation markers (CRP, alpha-1 antitrypsin) and metabolic characteristics (p=< 0.05). Metabolically healthy but obese postmenopausal women had significantly lower levels of C-reactive protein and alpha-1 antitrypsin compared to insulin-resistant obese women (P<0.05).
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