Key result
Metabolically healthy obesity was associated with lower fasting flow-mediated dilation (p<0.01) and greater inflammatory burden compared to normal-weight controls, but similar postprandial triglycerides.
Why the study?
The cardiovascular disease risk associated with metabolically healthy obesity remains controversial.
Does metabolically healthy obesity alter postprandial triglycerides, flow-mediated dilation, and inflammatory cytokines compared to normal-weight controls and metabolic syndrome?
Cross-Sectional
Does metabolically healthy obesity alter postprandial triglycerides, flow-mediated dilation, and inflammatory cytokines compared to normal-weight controls and metabolic syndrome?
p-value: p=<0.01
Metabolically healthy obesity is associated with baseline endothelial dysfunction and increased inflammation, but lacks the acute postprandial vascular impairment seen in metabolic syndrome.
MHO risk profiling via postprandial and inflammatory markers is hypothesis-generating; prospective studies needed before clinical adoption.
The cardiovascular disease (CVD) risk of metabolically healthy obesity (MHO) remains controversial. We sought to further characterize the CVD risk profile in MHO by evaluating postprandial triglycerides, vascular function, and systemic inflammatory markers. Control individuals that were normal-weight and metabolically healthy (Con), MHO, and metabolic syndrome (MetS) were recruited (n = 10–11/group). Each participant underwent an abbreviated fat tolerance test, fasting and postprandial flow-mediated dilation (FMD), and had a panel of inflammatory cytokines measured. MHO displayed postprandial triglycerides similar to those in Con and both MHO and Con had lower values than those for MetS (p < 0.01). Fasting FMD was lower in MHO and MetS compared to that of Con (p < 0.01), but during the postprandial period the vasodilatory response of MHO was similar to that while fasting (p = 0.39), while FMD in Con and MetS decreased after the high-fat meal (p values < 0.01). MHO displayed a number of inflammatory cytokines greater than those of Con and MetS (all p values < 0.05), while MetS and MHO had higher TNF-α than did Con (p < 0.05). In conclusion, MHO was associated with lower fasting FMD and a greater inflammatory burden but did not suffer the same negative postprandial effects as did MetS.
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Keirns et al. (2021) conducted a cross-sectional in Metabolically healthy obesity. Metabolically healthy obesity (MHO) vs. Normal-weight metabolically healthy (Con) and metabolic syndrome (MetS) was evaluated on Postprandial triglycerides, fasting and postprandial flow-mediated dilation (FMD), and inflammatory cytokines (p=<0.01). Metabolically healthy obesity was associated with lower fasting flow-mediated dilation (p<0.01) and greater inflammatory burden compared to normal-weight controls, but similar postprandial triglycerides.
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