Key result
Long-term propranolol treatment after acute myocardial infarction resulted in a sustained weight gain compared to placebo (mean difference 1.2 kg; 95% CI 0.9 to 1.5).
Why the study?
Does long-term propranolol treatment affect body weight in patients after acute myocardial infarction?
Population
3,837 men and women, 5-21 days after an acute myocardial infarction
Comparison
Propranolol for up to 40 months vs Placebo
Design
Cohort, randomised, double blind
Follow-up
up to 40 months
Authors
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May warrant weight monitoring in post-MI patients on propranolol; leaves open causal metabolic effects pending prospective trials.
RCT (n=3,837)
double blind
randomised
Does long-term propranolol treatment affect body weight in patients after acute myocardial infarction?
Effect estimate: mean difference 1.2 kg (95% CI 0.9 to 1.5)
Absolute Event Rate: 2.3% vs 1.2%
Long-term propranolol treatment after myocardial infarction is associated with a sustained, greater weight gain compared to placebo.
Rössner et al. (1990) conducted an RCT in acute myocardial infarction (n=3,837). propranolol vs. placebo was evaluated on Changes in body weight (mean difference 1.2 kg, 95% CI 0.9 to 1.5). Long-term propranolol treatment after acute myocardial infarction resulted in a sustained weight gain compared to placebo (mean difference 1.2 kg; 95% CI 0.9 to 1.5).
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