Why the study?
Does propranolol reduce mortality in patients who survived 1 year after myocardial infarction depending on their first-year clinical course?
Population
3,297 men and women 30 to 69 years of age who survived 1 year after myocardial infarction, from 31 clinical…
Comparison
Propranolol continued at 12 months after… vs Not receiving beta-blocker therapy at 12 months.
Design
Cohort, randomized, double-blind, placebo-controlled
Follow-up
720 days
Authors
Loading...
May support risk-stratified beta-blocker use in high-risk post-MI survivors; hypothesis-generating and requires randomized confirmation before practice change.
Does propranolol reduce mortality in patients who survived 1 year after myocardial infarction depending on their first-year clinical course?
Long-term beta-blocker therapy after myocardial infarction provides significant mortality benefit primarily in patients who experience a high-risk clinical course during the first year.
Catherine M. Viscoli (1993) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: