Key result
Metoprolol given as initial antihypertensive treatment significantly lowered total mortality compared to thiazide diuretics in white men aged 40 to 64 years.
Why the study?
Does metoprolol lower total mortality to a greater extent than thiazide diuretics as initial antihypertensive treatment in middle-aged white men with hypertension?
RCT (n=3,234)
Does metoprolol lower total mortality to a greater extent than thiazide diuretics as initial antihypertensive treatment in middle-aged white men with hypertension?
Initial antihypertensive treatment with metoprolol significantly reduces total mortality compared to thiazide diuretics in middle-aged men with hypertension.
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Supports metoprolol over thiazides as initial therapy in middle-aged white hypertensive men; confirms mortality reduction in this RCT population.
John Wikstrand (1988) conducted an RCT in Hypertension (n=3,234). Metoprolol vs. Thiazide diuretics (hydrochlorothiazide 46 mg/d or bendroflumethiazide 4.4 mg/d) was evaluated on Total mortality. Metoprolol given as initial antihypertensive treatment significantly lowered total mortality compared to thiazide diuretics in white men aged 40 to 64 years.
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