Key result
High NT-proBNP and depression scores in Eisenmenger syndrome linked to ~10-fold higher cardiac event risk.
Why the study?
Does the combination of depressive symptoms and elevated NT-proBNP predict cardiac events in patients with Eisenmenger syndrome?
Cohort (n=64)
Does the combination of depressive symptoms and elevated NT-proBNP predict cardiac events in patients with Eisenmenger syndrome?
Effect estimate: RR 9.6
p-value: p=< .001
The combination of depressive symptoms and elevated NT-proBNP levels strongly predicts future cardiac events in patients with Eisenmenger syndrome.
Hypothesis-generating for combined NT-proBNP and depression screening in Eisenmenger syndrome; prospective validation needed before clinical adoption.
OBJECTIVES: Eisenmenger syndrome (ES) is commonly associated with depressive symptoms and elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP). We investigated the predictive value of depressive symptoms and NTproBNP levels for long-term outcomes in patients with ES. METHODS: Blood was drawn to measure NT-proBNP, and depressive symptoms were measured using the Korean version of the Beck Depression Inventory (BDI) in an outpatient clinic sample of 64 patients with ES (67% female; median age = 41.5 years [range, 21.0-74.8 years]). Cardiac events (hospitalization, emergency department visits, and cardiac death) were monitored during 3 years of follow-up. RESULTS: During the follow-up period, 15 (23.4%) patients experienced a cardiac event. The combination of depressive symptoms and NT-proBNP levels better predicted future cardiac events than either variable alone. Patients with NT-proBNP > 510 pg/ml and a total BDI score > 10 had a 9.6 times higher risk for cardiac events than did patients with NT-proBNP ≤ 510 pg/ml or total BDI score ≤ 10 (p < .001). CONCLUSIONS: Depressive symptoms and NT-proBNP levels are both associated with adverse clinical outcomes in ES.
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Moon et al. (2015) conducted a cohort in Eisenmenger syndrome (n=64). Elevated NT-proBNP (> 510 pg/ml) and depressive symptoms (BDI > 10) vs. NT-proBNP ≤ 510 pg/ml or BDI ≤ 10 was evaluated on Cardiac events (hospitalization, emergency department visits, and cardiac death) (RR 9.6, p=< .001). Patients with Eisenmenger syndrome having NT-proBNP > 510 pg/ml and a Beck Depression Inventory score > 10 had a 9.6 times higher risk for cardiac events over 3 years (p < 0.001).
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