Key result
Elevated NT-proANP and corin in hypertensive pregnancy linked to adverse neonatal outcomes.
Why the study?
Atrial natriuretic peptide regulates water-salt balance and blood pressure, prompting investigation into plasma NT-proANP and corin in patients with hypertensive disorders of pregnancy and their relationship with neonatal adverse prognosis.
Are elevated plasma NT-proANP and corin levels associated with adverse neonatal outcomes in patients with hypertensive disorders of pregnancy?
Case-Control (n=125)
Are elevated plasma NT-proANP and corin levels associated with adverse neonatal outcomes in patients with hypertensive disorders of pregnancy?
Plasma NT-proANP and corin are elevated in hypertensive disorders of pregnancy and are independently associated with adverse neonatal outcomes such as premature delivery, lower neonatal weight, and lower APGAR scores.
Answers are grounded in this paper and cite their sources.
NT-proANP and corin elevations were associated with adverse neonatal outcomes in HDP; hypothesis-generating and should not yet change practice.
INTRODUCTION: Atrial natriuretic peptide (ANP) regulates water-salt balance and blood pressure by promoting renal sodium and water excretion. OBJECTIVE: Our study was to investigate plasma N-terminal pro-atrial natriuretic peptide (NT-proANP) and corin in hypertensive disorders of pregnancy (HDP) patients. Furthermore, the relationship between corin/NT-proANP and neonatal adverse prognosis were evaluated. METHODS: Seventy-seven HDP patients and forty-eight normotensive women as control group were recruited. Clinical characteristic and plasma were collected. Plasma NT-proANP and corin were determined by ELISA. Gestational age, neonatal weight and APGAR scores were recorded. Statistical analysis was conducted. RESULTS: NT-proANP and corin were significantly increased in HDP group compared with that of control (P < 0.05). NT-proANP and corin were significantly elevated in HDP patients who suffered from premature delivery (P < 0.05). Both NT-proANP and corin were negatively associated with delivery time, neonatal weight and APGAR scores in HDP group. Multiple regressions demonstrated that NT-proANP and corin were independent risk factor of delivery time, neonatal weight and APGAR scores. CONCLUSIONS: Plasma NT-proANP and corin were significantly increased in HDP. NT-proANP and corin were associated with neonatal adverse events in HDP patients. Thus, NT-proANP and corin may become new biomarkers for evaluating severity of pregnancy and neonatal adverse events in HDP patients.
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Lin et al. (2020) conducted a case-control in Hypertensive disorders of pregnancy (n=125). Plasma NT-proANP and corin levels vs. Normotensive pregnant women was evaluated on Plasma NT-proANP and corin levels and their association with delivery time, neonatal weight and APGAR scores (p=< 0.05). Plasma NT-proANP and corin were increased in patients with hypertensive disorders of pregnancy and were independent risk factors for adverse neonatal outcomes.
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