Key result
Higher NT-proBNP concentrations in early pregnancy were associated with a lower risk of hypertensive disorders of pregnancy (OR per doubling 0.81; 95% CI 0.73-0.91) and future incident hypertension.
Why the study?
Hypertensive disorders of pregnancy are linked to future cardiovascular disease, but whether early-pregnancy NT-proBNP concentrations are associated with hypertensive disorders of pregnancy and subsequent postpartum hypertension was unknown.
Are higher NT-proBNP concentrations in early pregnancy associated with a lower risk of hypertensive disorders of pregnancy and future hypertension in nulliparous women?
Population
4103 nulliparous women without prepregnancy hypertension or diabetes at 8 clinical sites
Comparison
NT-proBNP concentration measured from a first-trimester blood sample
Design
Prospective multicenter observational cohort study
Follow-up
2 to 7 years after pregnancy
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Suggests early-pregnancy NT-proBNP may help stratify maternal cardiovascular risk; leaves open.
Cohort (n=4,103)
Yes
Are higher NT-proBNP concentrations in early pregnancy associated with a lower risk of hypertensive disorders of pregnancy and future hypertension in nulliparous women?
Odds Ratio: 0.81 (95% CI 0.73–0.91)
Higher NT-proBNP concentrations in early pregnancy are associated with a lower risk of developing hypertensive disorders of pregnancy and incident hypertension 2 to 7 years postpartum.
A 2022 study conducted a cohort in Hypertensive disorders of pregnancy and future hypertension (n=4,103). NT-proBNP concentration in early pregnancy was evaluated on Hypertensive disorders of pregnancy (OR 0.81, 95% CI 0.73-0.91). Higher NT-proBNP concentrations in early pregnancy were associated with a lower risk of hypertensive disorders of pregnancy (OR per doubling 0.81; 95% CI 0.73-0.91) and future incident hypertension.
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