Key result
First-trimester NT-proBNP levels strongly predicted low birth weight in pregnancies with chronic hypertension (AUC 0.842, p<0.001; OR 1.03, 95% CI 1.01-1.04).
Why the study?
The prognostic value of NT-proBNP in pregnancies with isolated chronic hypertension was unknown.
Do first trimester NT-proBNP levels predict perinatal complications such as low birth weight in pregnancies with chronic hypertension?
Case-Control (n=74)
No
Do first trimester NT-proBNP levels predict perinatal complications such as low birth weight in pregnancies with chronic hypertension?
Odds Ratio: 1.03 (95% CI 1.01–1.04)
p-value: p=<0.001
First-trimester NT-proBNP levels can serve as a useful prognostic biomarker for predicting low birth weight in pregnant women with chronic hypertension.
NT-proBNP may aid low birth weight risk stratification in chronic hypertension pregnancies; leaves open prospective validation before clinical use.
Background: This study aimed to investigate the prognostic value of N-terminal B-type natriuretic peptide (NT-proBNP) in pregnancies with isolated chronic hypertension (HT).Method: 34 pregnant women with chronic HT and 40normotensive controls were enrolled. The association between plasma NT-proBNP levels obtained in the first trimester and perinatal complications were evaluated.Results: NT-proBNP levelsstrongly predicted low birth weight (AUC=0.842, p<0.001). NT-proBNP and birth weight were negatively correlated (r= -0.323, p=0.005). NT-proBNP was found to be an individual determinant of low birth weight in univariate analysis (OR:1.03; 95%CI:1.01-1.04).Conclusion: NT-proBNP levels can be useful to predict low birth weight in pregnancies with chronic HT.
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Erdöl et al. (2021) conducted a case-control in Pregnancies with isolated chronic hypertension (n=74). First-trimester NT-proBNP levels vs. Normotensive controls was evaluated on Low birth weight (OR 1.03, 95% CI 1.01-1.04, p=<0.001). First-trimester NT-proBNP levels strongly predicted low birth weight in pregnancies with chronic hypertension (AUC 0.842, p<0.001; OR 1.03, 95% CI 1.01-1.04).
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