Key result
Patient age ≥60 years, tumor stage, and proximal anatomic sites were significant predictors of poorer survival in extremity liposarcoma, which had an overall survival rate of 68%.
Why the study?
What are the prognostic factors that significantly influence survival outcomes in patients with extremity liposarcoma?
Cohort (n=211)
No
What are the prognostic factors that significantly influence survival outcomes in patients with extremity liposarcoma?
Age, tumor stage, and anatomic site are significant prognostic indicators for survival in patients with extremity liposarcoma.
May support risk stratification by age, stage, and site in extremity liposarcoma; leaves open prospective validation.
Background: Over the past 30 years, the Orthopedic Oncology Service at the Massachusetts General Hospital has treated 211 patients with liposarcomas of the extremities. Materials & methods: Using records maintained in a specifically designed computer system, a retrospective study was conducted that was designed to identify prognostic factors that significantly influence survival outcomes. Results: The overall survival rate for the group of patients was 68% with a mean follow-up of 10.5 ± 6.9 years. Patient gender had no effect on survival outcome, but age of the patient was significantly correlated with survival data, with the poorest survival for patients aged 60 years or older. The Musculoskeletal Tumor Society Stage of the lesion had a profound effect on outcome. In addition, anatomic site was correlated with survival outcomes with a 70 and 64% survival for patients with lesion about the shoulder or pelvis, compared with a 100% survival for tumors of the leg, ankle and foot, and 83% for arm, forearm an...
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Roque et al. (2007) conducted a cohort in Extremity liposarcoma (n=211). Prognostic factors (age, stage, anatomic site) was evaluated on Overall survival. Patient age ≥60 years, tumor stage, and proximal anatomic sites were significant predictors of poorer survival in extremity liposarcoma, which had an overall survival rate of 68%.
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