Key result
Older age, prolonged surgery, and tumor necrosis linked to substantially higher short-term retroperitoneal liposarcoma recurrence risk.
Why the study?
Because primary retroperitoneal liposarcoma is rare, related clinical studies are lacking to evaluate predictive factors for recurrence and recurrence-free survival.
What are the predictive factors for short-term recurrence and local recurrence-free survival in patients with surgically resected primary retroperitoneal liposarcoma?
Cohort (n=128)
What are the predictive factors for short-term recurrence and local recurrence-free survival in patients with surgically resected primary retroperitoneal liposarcoma?
Age, operative time, tumor necrosis, clinical symptoms, resection method, and histological subtype predict recurrence in surgically resected primary retroperitoneal liposarcoma, enabling the construction of a novel predictive nomogram.
Answers are grounded in this paper and cite their sources.
May inform risk-stratified surveillance after resection; supports nomogram development but leaves open need for prospective validation.
Since primary retroperitoneal liposarcoma (PRPLS) is rare in the clinic, related clinical studies are lacking. The present study was designed to investigate the predictive factors of short-term (≤1 year) recurrence (STR) and construct a novel nomogram of local recurrence-free survival (LRFS) for surgically resected PRPLS. A total of 128 PRPLS cases who underwent radical surgery were retrospectively analyzed. Based on the interval from the operation to tumor recurrence, the predictors of STR were screened using univariate and multivariate logistic regression analyses. Cox proportional hazard regression models were applied to identify the predictors of LRFS. Furthermore, the independent predictors acquired from multivariate analyses were used to construct a nomogram. Multivariate logistic regression analysis revealed that age ≥55 years [odds ratio (OR)=5.607, P=0.010], operative time ≥260 min (OR=9.716, P=0.005) and tumor necrosis (OR=3.781, P=0.037) were independent risk factors of STR for PRPLS. In the Cox regression analysis, clinical symptoms [hazard ratio (HR)=1.746, P=0.017], resection method (OR=0.370, P=0.021) and de-differentiated histological subtype (HR=1.975, P=0.048) were identified as independent predictors of LRFS. Subsequently, the independent predictors acquired from multivariate analyses were used to construct a nomogram for LRFS. Age, operative time, tumor necrosis, clinical symptoms, resection method and histological subtype were related to recurrence for surgically resected PRPLS and a novel nomogram was constructed based on the above predictors.
No takes yet. Share an insight, caveat, or question.
Yu et al. (2023) conducted a cohort in Primary retroperitoneal liposarcoma (n=128). Radical surgery was evaluated on Short-term (≤1 year) recurrence (STR) and local recurrence-free survival (LRFS). Age ≥55 years (OR 5.607), operative time ≥260 min (OR 9.716), and tumor necrosis (OR 3.781) were independent risk factors for short-term recurrence of primary retroperitoneal liposarcoma.
Synapse has enriched 10 related papers. Consider them for comparative context: