Key result
Blockade of the renin-angiotensin system showed similar efficacy in reversing established hypertension and hypertrophy in adult rats compared to preventing development in young rats.
Why the study?
Does chronic inhibition of the renin-angiotensin system reverse established hypertension and hypertrophy in adult genetically hypertensive rats similarly to its prevention in young rats?
Systematic Review
Does chronic inhibition of the renin-angiotensin system reverse established hypertension and hypertrophy in adult genetically hypertensive rats similarly to its prevention in young rats?
RAS blockade appears similarly effective in reversing established hypertension and hypertrophy in adult rats as it is in preventing their development in young rats.
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Supports equivalent RAS blockade efficacy for reversal in adult versus prevention in young hypertensive rats; extends preclinical models while leaving human translation open.
Lundie et al. (1997) conducted a systematic review in Genetic hypertension. Inhibition of the renin-angiotensin system (ACE inhibitor or ARB) vs. Young genetically hypertensive rats was evaluated on Persistent downregulation of hemodynamic and cardiovascular structural changes. Blockade of the renin-angiotensin system showed similar efficacy in reversing established hypertension and hypertrophy in adult rats compared to preventing development in young rats.
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