Key result
FK-739 caused a greater decrease in LV collagen content (3.06 vs 3.47 mg/g, p=0.015) and greater LV distensibility compared to enalapril in spontaneously hypertensive rats.
Why the study?
Does FK-739 improve LV distensibility and collagen metabolism compared to enalapril in spontaneously hypertensive rats?
Does FK-739 improve LV distensibility and collagen metabolism compared to enalapril in spontaneously hypertensive rats?
Absolute Event Rate: 3.06% vs 3.47%
p-value: p=0.015
In spontaneously hypertensive rats, AT1-receptor blockade with FK-739 improved LV distensibility and reduced collagen content more effectively than ACE inhibition with enalapril, despite similar blood pressure lowering.
Does not support clinical use in hypertension; leaves open whether AT1 blockade reduces LV fibrosis more than ACE inhibition in patients.
We compared the cardiac effects of the selective angiotensin II type 1 (AT1)-receptor blockade, FK-739, with an angiotensin-converting-enzyme (ACE) inhibitor, enalapril, on left ventricular (LV) distensibility and collagen metabolism in spontaneously hypertensive rats (SHRs). We treated 14-week-old SHRs with FK-739 (30 mg/kg/day) or enalapril (10 mg/kg/day) for 6 weeks. Both FK-739 and enalapril induced a significant decrease in blood pressure (p < 0.001) and regression of LV hypertrophy (p < 0.001) compared with vehicle, with no differences between the treated groups. Furthermore, FK-739 caused a greater decrease in LV collagen content than did enalapril (FK-739-treated group, 3.06 +/- 0.11 mg/g; enalapril-treated group, 3.47 +/- 0.05 mg/g; p = 0.015) with no change in collagen phenotypes. Hearts taken from rats treated with FK-739 also showed greater LV distensibility than those taken from enalapril-treated rats (FK-739-treated group vs. enalapril-treated group at > or = 15 mm Hg, p < 0.001). These results suggest that, compared with ACE inhibition, AT1-receptor blockade may have additional effects on LV distensibility and collagen metabolism in the regression of LV hypertrophy induced by pressure overload.
No takes yet. Share an insight, caveat, or question.
Yonezawa et al. (1996) studied Hypertension and left ventricular hypertrophy. FK-739 vs. Enalapril (10 mg/kg/day) and vehicle was evaluated on Left ventricular (LV) collagen content (p=0.015). FK-739 caused a greater decrease in LV collagen content (3.06 vs 3.47 mg/g, p=0.015) and greater LV distensibility compared to enalapril in spontaneously hypertensive rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: