What is the clinical evidence from this study?

Study design: Review. Population: Hypertension and cardiac hypertrophy.

January 1, 1992

Mechanisms of cardiac growth. The role of the renin-angiotensin system

View Full Paper

Ask AI

Bookmark

Key result

Cardiac hypertrophy in hypertension is likely triggered by a synergistic link between high blood pressure, the renin-angiotensin system, and other vasoactive systems.

Design

Review

Authors

MFMaría S. Fernández‐AlfonsoUniversidad Complutense de Madrid DGDetlev GantenGeneral / Preventive / Lipids MPM. PaulRamakrishna Mission Vivekananda Educational and Research Institute

Discussion

Member takes

Implication

Should not yet change LVH management in hypertension; leaves open validation of synergistic BP-RAS mechanisms.

PICO

Population

Hypertension and cardiac hypertrophy

This review emphasizes the multifactorial nature of left ventricular hypertrophy, highlighting the synergistic roles of mechanical stress and the renin-angiotensin system.

Limitations

In vivo studies of pressure overload by aortic coarctation cannot exclude the contribution of humoral factors like angiotensin II.
In vitro studies are limited by the difficulty of imposing overload on cardiocytes.

Cite This Study

Fernández-Alfonso et al. (1992) conducted a review in Hypertension and cardiac hypertrophy. Cardiac hypertrophy in hypertension is likely triggered by a synergistic link between high blood pressure, the renin-angiotensin system, and other vasoactive systems.

synapsesocial.com/papers/6a0ccb7a243f79c7af34c567 https://doi.org/10.1007/978-3-642-72477-0_15

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Mechanisms of cardiac growth. The role of the renin-angiotensin system

Discussion

Member takes

Implication

PICO

Limitations

Cite This Study

Topics

Mechanisms of cardiac growth. The role of the renin-angiotensin system

Discussion

Member takes

Implication

PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider