Key result
Chronic pulmonary hypertension significantly reduced propagation velocities of main RV (28 vs 40 cm/sec; P<0.0001) and LV (37 vs 52 cm/sec; P<0.0003) diastolic flows compared to normal controls.
Why the study?
Does chronic pulmonary hypertension cause interventricular spatiotemporal dyssynchrony as assessed by Color M-mode echocardiography?
Observational (n=50)
Does chronic pulmonary hypertension cause interventricular spatiotemporal dyssynchrony as assessed by Color M-mode echocardiography?
Chronic pulmonary hypertension causes significant interventricular diastolic dyssynchrony and reduces propagation velocities of diastolic signals in both ventricles.
May indicate biventricular diastolic dyssynchrony on color M-mode; leaves open prognostic value and need for prospective validation.
BACKGROUND: Color M-mode (CMM) has been useful in characterizing left ventricular (LV) relaxation as well as providing information regarding right ventricular (RV) filling dynamics and pressure gradients. The spatiotemporal resolution of CMM offers a unique opportunity to study the effect of chronic pulmonary hypertension (cPH) on biventricular diastolic function. METHODS: Propagation velocities of LV and RV diastolic flows were obtained from 20 individuals with normal pulmonary artery systolic pressures, designated Group I (mean age 50 ± 12 years and 32 ± 6 mmHg) and from 30 patients with cPH, designated Group II (mean age 55 ± 14 years and 81 ± 25 mmHg). RESULTS: Group II patients not only had a significant difference between RV and LV onset of early (13 ± 55 vs. -223 ± 333 msec; P < 0.003) and late (-494 ± 467 vs. -125 ± 258 msec; P < 0.001) diastolic flows; but also had lower propagation velocities of the main RV (40 ± 10 vs. 28 ± 10 cm/sec; P < 0.0001) and LV (52 ± 11 vs. 37 ± 15 cm/sec; P < 0.0003) diastolic flows than Group I individuals. CONCLUSIONS: It appears that cPH disrupts not only RV and LV diastolic signal distribution but also their temporal occurrence as well as reducing the propagation velocities of the main diastolic signals in both ventricles. These results seem to imply that cPH causes significant interventricular diastolic dyssynchrony and further studies are now needed to correlate these findings with regard to symptoms and patient clinical outcomes.
No takes yet. Share an insight, caveat, or question.
López‐Candales et al. (2012) conducted an observational in Chronic pulmonary hypertension (n=50). Chronic pulmonary hypertension vs. Normal pulmonary artery systolic pressures was evaluated on Propagation velocities and onset of early and late diastolic flows of the right and left ventricles. Chronic pulmonary hypertension significantly reduced propagation velocities of main RV (28 vs 40 cm/sec; P<0.0001) and LV (37 vs 52 cm/sec; P<0.0003) diastolic flows compared to normal controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: