September 5, 2007Molecular and Cellular BiologyOpen Access

Cardiac-Myocyte-Specific Excision of the Vinculin Gene Disrupts Cellular Junctions, Causing Sudden Death or Dilated Cardiomyopathy

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Population

Mouse model with cardiac-myocyte-specific inactivation of the vinculin (Vcl) gene using Cre-loxP technology

Design

Preclinical

Follow-up

up to 6 months of age

Authors

AZAlice E. Zemljic‐HarpfCalifornia College San Diego JMJ. MillerUniversity of California, San Diego SHScott A. HendersonUniversity of California, Los Angeles

Discussion

Member takes

Implication

Cardiac vinculin is essential in mice; leaves open its role in human cardiomyopathy and arrhythmias.

Structured PICO

Population

Mouse model with cardiac-myocyte-specific inactivation of the vinculin (Vcl) gene using Cre-loxP technology

Intervention

Cardiac-myocyte-specific inactivation of the vinculin (Vcl) gene

Outcome

Cardiac phenotype including sudden death, ventricular tachycardia, dilated cardiomyopathy, and ultrastructural changes in heart tissue

Cardiac-myocyte-specific inactivation of the vinculin gene demonstrates its essential role in maintaining myocardial cellular junctions, with its loss causing fatal ventricular tachycardia and dilated cardiomyopathy.

Cite This Study

Zemljic‐Harpf et al. (2007) studied this question.

synapsesocial.com/papers/6a0cd1cd3fce92745334d295 https://doi.org/10.1128/mcb.00728-07

Topics

Ventricular arrhythmias

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Cardiac-Myocyte-Specific Excision of the Vinculin Gene Disrupts Cellular Junctions, Causing Sudden Death or Dilated Cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Cardiac-Myocyte-Specific Excision of the Vinculin Gene Disrupts Cellular Junctions, Causing Sudden Death or Dilated Cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

Also Consider