Review of the mechanism of processive actin filament elongation by formins
Key result
Formins direct the assembly of unbranched actin filaments by remaining bound to barbed ends, with FH1 domains rapidly transferring actin to allow elongation exceeding free monomer diffusion rates.
Design
Review
Authors
Discussion
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Member takes
Implication
Advances cytoskeletal research in cardiovascular cells; leaves open links to remodeling or fibrosis.
PICO
P
Population
Actin filament elongation
I
Intervention / Comparator
Formins
This review summarizes the biophysical mechanisms by which formins direct the assembly and elongation of unbranched actin filaments.
Cite This Study
Paul et al. (2009) conducted a review in Actin filament elongation. Formins was evaluated. Formins direct the assembly of unbranched actin filaments by remaining bound to barbed ends, with FH1 domains rapidly transferring actin to allow elongation exceeding free monomer diffusion rates.