Key result
Micromolar concentrations of Ca2+ induce a conformational change in the complex of F actin with regulatory proteins tropomyosin and troponin, as indicated by changes in correlation time theta2.
Micromolar concentrations of Ca2+ induce a conformational change in the complex of F actin with the regulatory proteins tropomyosin and troponin.
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Extends molecular models of thin-filament Ca2+ regulation; leaves open translation to intact cardiac physiology or therapy.
Tawada et al. (1978) studied this question. Micromolar concentrations of Ca2+ induce a conformational change in the complex of F actin with regulatory proteins tropomyosin and troponin, as indicated by changes in correlation time theta2.
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