Population
Actin molecules labeled with fluorescein-5-isothiocyanate (FITC) at Lys-61 or Cys-374
Comparison
Polymerization, myosin subfragment-1 binding… vs Unpolymerized actin or actin without…
Design
Preclinical
Authors
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No immediate clinical implications; leaves open further mapping of actin binding interfaces in muscle regulation.
Lys-61 in actin appears to be located near actin-actin contact regions and binding sites for myosin subfragment-1 and regulatory proteins.
Miki et al. (1988) studied this question.
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