Key result
Type 1 diabetes was associated with reduced LDL size in women (P=0.0009) and higher HDL size in both sexes (P<0.0001), but particle size did not correlate with coronary calcification in diabetics.
Why the study?
Do lipoprotein particle sizes and subclasses differ in patients with type 1 diabetes compared to controls, and how do they relate to coronary artery calcification?
Case-Control (n=389)
Do lipoprotein particle sizes and subclasses differ in patients with type 1 diabetes compared to controls, and how do they relate to coronary artery calcification?
Type 1 diabetes alters NMR-derived lipoprotein particle sizes, particularly reducing LDL size in women, but the relationship between these particle sizes and coronary calcification is unclear in diabetic patients unlike in the general population.
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Particle sizes should not guide CAC assessment in T1D; leaves open mechanistic links to calcification.
Colhoun et al. (2002) conducted a case-control in Type 1 diabetes (n=389). Type 1 diabetes vs. Age- and sex-matched control subjects was evaluated on Lipoprotein particle sizes and subclasses and relationship to coronary artery calcification. Type 1 diabetes was associated with reduced LDL size in women (P=0.0009) and higher HDL size in both sexes (P<0.0001), but particle size did not correlate with coronary calcification in diabetics.
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