Key result
Neutrophil-to-lymphocyte ratio ≥8.4 linked to ~153% higher 30-day mortality vs <4.0 in critically ill CHF.
Why the study?
The study aimed to explore the association between the neutrophil-to-lymphocyte ratio and the prognosis of critically ill chronic heart failure patients.
Does a higher neutrophil-to-lymphocyte ratio predict increased 30-day and 90-day mortality in critically ill patients with chronic heart failure?
Cohort (n=5,298)
Does a higher neutrophil-to-lymphocyte ratio predict increased 30-day and 90-day mortality in critically ill patients with chronic heart failure?
Answers are grounded in this paper and cite their sources.
An elevated neutrophil-to-lymphocyte ratio is an independent predictor of significantly increased 30-day and 90-day all-cause mortality in critically ill patients with chronic heart failure.
The present study aimed to explore the association between the neutrophil-to-lymphocyte ratio (NLR) and prognosis of critically ill chronic heart failure patients. The records of 5298 patients who met the inclusion criteria were extracted from the Medical Information Mart for Intensive Care IV database. The primary outcome was 30-days all-cause mortality and the secondary outcome was 90-days all-cause mortality. Multivariable logistic regression analysis was performed to examine the relationship between NLR and 30-days mortality. Subgroup analysis was carried out to identify whether the association between NLR and 30-days mortality differed across various subgroups. For 30-days mortality, after adjusting for multiple confounders, the odds ratio (OR) (95% confidence interval [CI]) for the second (NLR 4.0-8.4) and the third (NLR ≥8.4) tertiles were 1.52 (1.13-2.03) and 2.53 (1.92-3.34), respectively, compared with the first tertile (NLR <4.0). As for 90-days mortality, the OR for the second (NLR 4.0-8.4) was 1.34 (1.07-1.67) and 2.23 (1.81-2.76) for the third (NLR ≥8.4) tertiles compared with the reference (NLR<4.0). The interactions between the sepsis subgroup and 30-days mortality were significant. Our study concluded that the NLR was an independent predictor of 30- and 90-days mortality for critically ill patients with chronic heart failure.
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Che et al. (2023) conducted a cohort in chronic heart failure (n=5,298). Neutrophil-to-lymphocyte ratio (NLR) vs. NLR <4.0 (first tertile) was evaluated on 30-days all-cause mortality (OR 2.53, 95% CI 1.92-3.34). A neutrophil-to-lymphocyte ratio ≥8.4 was associated with increased 30-day all-cause mortality compared to a ratio <4.0 in critically ill chronic heart failure patients.
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