Key result
A low relative lymphocyte concentration (<20.3%) was an independent predictor of mortality in advanced heart failure, with 4-year survival of 34% compared to 73% for normal levels (P=0.004).
Why the study?
Does a low relative lymphocyte concentration predict reduced survival and transplant-free survival in patients with advanced heart failure?
Cohort (n=211)
No
Does a low relative lymphocyte concentration predict reduced survival and transplant-free survival in patients with advanced heart failure?
Absolute Event Rate: 34% vs 73%
p-value: p=.004
A low relative lymphocyte concentration (<20.3%) is a simple, independent prognostic marker for reduced survival and transplant-free survival in patients with advanced heart failure.
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May aid prognostication in advanced HF without changing practice; leaves open prospective validation in risk models.
Ommen et al. (1998) conducted a cohort in Advanced heart failure (n=211). Low percentage of lymphocytes (<20.3%) vs. Normal percentage of lymphocytes was evaluated on Time to death (p=.004). A low relative lymphocyte concentration (<20.3%) was an independent predictor of mortality in advanced heart failure, with 4-year survival of 34% compared to 73% for normal levels (P=0.004).
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