Key result
Adults with congenital heart disease had significantly elevated neurohormones compared to healthy controls, including ANP (56.6 vs 3.1 pmol/L) and BNP (35.8 vs 5.7 pmol/L, P<0.0001).
Population
53 adults with congenital heart disease, mean age 33.5±1.5 years, 29 female, NYHA class 2.0±0.1, and 15…
Design
Case-control, Systemic ventricular function was graded by a blinded…
Authors
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Elevated neurohormones associate with ACHD severity; hypothesis-generating for targeted therapy but should not yet change practice.
Observational (n=68)
Single-blind
p-value: p=<0.0001
Neurohormonal activation is significantly elevated in adults with congenital heart disease and correlates with symptom severity and ventricular dysfunction, highlighting a potential therapeutic target.
Bolger et al. (2002) conducted an observational in Congenital heart disease (n=68). Congenital heart disease vs. Healthy controls was evaluated on Neurohormonal activation (ANP, BNP, ET-1, renin, aldosterone, norepinephrine) (p=<0.0001). Adults with congenital heart disease had significantly elevated neurohormones compared to healthy controls, including ANP (56.6 vs 3.1 pmol/L) and BNP (35.8 vs 5.7 pmol/L, P<0.0001).
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