Key result
Cardiac autonomic nervous activity indices decreased from normal to NYHA II (P<0.001), while neurohormonal indices increased in NYHA III-IV (P<0.001) in stable postoperative congenital heart disease.
Why the study?
Can cardiac autonomic nervous activity and neurohormonal activities stratify heart failure severity in stable postoperative congenital heart disease patients?
Population
379 subjects
Comparison
Measurement of cardiac autonomic nervous… vs Comparison across NYHA classes and between CHD…
Design
Cross-sectional
Authors
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May aid HF stratification in stable postoperative CHD; hypothesis-generating pending prospective validation.
Cross-Sectional (n=379)
Can cardiac autonomic nervous activity and neurohormonal activities stratify heart failure severity in stable postoperative congenital heart disease patients?
p-value: p=<0.001
CANA and NHA indices are useful for stratifying mild and severe heart failure in stable postoperative CHD patients, though age and surgery-related influences must be considered.
Ohuchi et al. (2003) conducted a cross-sectional in Congenital heart disease (n=379). Heart failure severity (NYHA class) vs. Control subjects was evaluated on Cardiac autonomic nervous activity (CANA) and neurohormonal activities (NHA) (p=<0.001). Cardiac autonomic nervous activity indices decreased from normal to NYHA II (P<0.001), while neurohormonal indices increased in NYHA III-IV (P<0.001) in stable postoperative congenital heart disease.
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