Key result
AVNRT with or without Brugada pattern linked to ~19 ms longer atrial conduction time versus controls.
Why the study?
Total atrial conduction time reflects atrial remodeling and arrhythmic substrate, but its status in AVNRT patients with and without drug-induced type 1 Brugada ECG pattern compared with controls was uncharacterized.
Is total atrial conduction time prolonged in patients with AVNRT compared to healthy controls?
Case-Control (n=104)
Is total atrial conduction time prolonged in patients with AVNRT compared to healthy controls?
Total atrial conduction time is prolonged in patients with AVNRT compared to healthy controls, suggesting underlying atrial remodeling regardless of the presence of a drug-induced Brugada pattern.
Answers are grounded in this paper and cite their sources.
Supports atrial remodeling in AVNRT; leaves open prognostic or therapeutic implications.
PURPOSE: The time interval between the onset of the P-wave on electrocardiogram (ECG) and peak A' velocity of the lateral left atrial wall assessed by tissue Doppler imaging (PA-TDI interval) determine total atrial conduction time (TACT) which reflects atrial remodeling and arrhythmic substrate. In this retrospective study, we aimed to assess TACT in patients with atrioventricular nodal reentrant tachycardia (AVNRT) with and without drug-induced type 1 Brugada electrocardiogram ECG pattern (DI-Type 1 BrP) and control subjects. METHODS: Study population consisted of 62 consecutive patients (46 women; mean age 44 ± 12 years) undergoing electrophysiological study and ablation for symptomatic, drug-resistant AVNRT, and 42 age-matched and sex-matched control subjects. All patients and control subjects underwent ajmaline challenge test and tissue Doppler imaging. RESULTS: A DI-Type 1 BrP was uncovered in 24 of 62 patients with AVNRT (38.7%). PA-TDI interval was similar among AVNRT patients with and without DI-Type 1 BrP (124 ± 12 ms vs 119 ± 14 ms, respectively, P = .32), but significantly longer in patients with AVNRT with as well as without DI-Type 1 BrP than in control subjects (124 ± 12 ms and 119 ± 14 ms vs 105 ± 11 ms, respectively, P < .001). CONCLUSION: The TACT assessed by PA-TDI interval is longer in patients with AVNRT with and without DI-Type 1 BrP than in age-matched and sex-matched healthy control subjects.
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Kocabaş et al. (2021) conducted a case-control in Atrioventricular nodal reentrant tachycardia (AVNRT) (n=104). AVNRT with and without drug-induced type 1 Brugada pattern vs. Healthy control subjects was evaluated on Total atrial conduction time (TACT) assessed by PA-TDI interval (p=<.001). AVNRT with and without drug-induced type 1 Brugada pattern was associated with significantly longer total atrial conduction time compared to healthy controls (124 and 119 ms vs 105 ms; P<.001).
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