Key result
Functional neural mechanisms, including rapid (> 1.5 Hz) pulse phasic discharge causing sympathetic disinhibition, contribute importantly to altered baroreflex responses in aging and disease.
Population
Cultured baroreceptor neurons and in vivo models (mechanistic studies of arterial baroreflex)
Design
Review
Authors
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Supports neural-focused baroreflex assessment in aging and disease; leaves open whether targeting these mechanisms alters outcomes.
Functional neural mechanisms, in addition to structural vascular changes, are important contributors to altered baroreflex responses in aging and cardiovascular diseases.
Chapleau et al. (1995) conducted a review in Hypertension, atherosclerosis, and aging. Functional neural mechanisms, including rapid (> 1.5 Hz) pulse phasic discharge causing sympathetic disinhibition, contribute importantly to altered baroreflex responses in aging and disease.
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