Key result
Percutaneous pulmonary artery denervation plus GDMT shows promise for treating isolated post-capillary pulmonary hypertension.
Why the study?
While percutaneous pulmonary artery denervation demonstrates long-term benefits in combined post- and pre-capillary pulmonary hypertension, its usefulness for isolated post-capillary pulmonary hypertension remains unclear.
Does percutaneous pulmonary artery denervation (PADN) improve outcomes in patients with isolated post-capillary pulmonary hypertension (IpcPH) due to left heart failure?
Case Report (n=2)
Does percutaneous pulmonary artery denervation (PADN) improve outcomes in patients with isolated post-capillary pulmonary hypertension (IpcPH) due to left heart failure?
Answers are grounded in this paper and cite their sources.
Percutaneous pulmonary artery denervation may be a promising adjunctive treatment option for patients with isolated post-capillary pulmonary hypertension due to left heart failure.
Although percutaneous pulmonary artery denervation (PADN) has demonstrated long-term benefits in combined post- and pre-capillary pulmonary hypertension, its usefulness for isolated post-capillary pulmonary hypertension (IpcPH) remains unclear. This report presents 2 cases of IpcPH due to left heart failure who underwent PADN treatment following an insufficient response to optimized conventional therapy. This case study illustrates how PADN, when combined with heart failure guideline-directed medical therapy, may represent a promising treatment option for IpcPH.
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Zhang et al. (2025) conducted a case report in Isolated post-capillary pulmonary hypertension (IpcPH) associated with heart failure (n=2). Percutaneous pulmonary artery denervation (PADN) was evaluated. Percutaneous pulmonary artery denervation combined with guideline-directed medical therapy may represent a promising treatment option for isolated post-capillary pulmonary hypertension.
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