What question did this study set out to answer?

This research investigates the role of suction in diastolic ventricular filling and its relationship with left ventricular pressure.

January 1, 1982Japanese Circulation JournalOpen Access

Left ventricular diastolic suction as a mechanism of ventricular filling.

Q: What is the clinical evidence from this study?

Study design: Other. Population: Left ventricular diastolic filling. Intervention: Transient occlusion of the mitral orifice vs. Control condition. Primary outcome: Minimal diastolic LV pressure (LVPmin).

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Key result

Transient occlusion of the mitral orifice in open chest dogs decreased minimal diastolic LV pressure below zero in >80% of runs, suggesting LV suction plays an important role in diastolic filling.

Why the study?

Does transient mitral orifice occlusion and increased inotropic state induce negative left ventricular pressure indicative of LV suction in open chest dogs?

Population

open chest dogs

Comparison

Transient occlusion of the mitral orifice to… vs Control condition (baseline inotropic state)

Design

Preclinical

Authors

MHMasatsugu HoriHeart Failure & Transplant EYEDWARD L YELIIN ESEdmund H. SonnenblickUniversity of Parma

Discussion

Member takes

Implication

Does not change practice; leaves open LV suction's role in human diastolic filling.

Key Points

This research investigates the role of suction in diastolic ventricular filling and its relationship with left ventricular pressure.
Occluded mitral orifice in open chest dogs to prevent left ventricular filling.
Measured minimal diastolic left ventricular pressure (LVPmin) under varying hemodynamic conditions.
Examined diastolic pressure-volume relationships during control and high inotropic states.
In over 80% of runs, LVPmin decreased below zero after mitral valve occlusion, remaining negative throughout diastole.
Negative LVPmin increased with decreased end-systolic volume and enhanced inotropic state.
Demonstrated correlation between LVPmin, left ventricular volume, and contractility.

Structured PICO

Does transient mitral orifice occlusion and increased inotropic state induce negative left ventricular pressure indicative of LV suction in open chest dogs?

Population

open chest dogs

Intervention

Transient occlusion of the mitral orifice to prevent left ventricular filling, with and without high inotropic state (Ca++ infusion)

Comparator

Control condition (baseline inotropic state)

Outcome

Minimal diastolic left ventricular pressure (LVPmin)surrogate

This study provides physiological evidence that left ventricular suction, driven by decreased end-systolic volume and increased contractility, plays an important role in diastolic filling.

Cite This Study

Hori et al. (1982) studied Left ventricular diastolic filling. Transient occlusion of the mitral orifice vs. Control condition was evaluated on Minimal diastolic LV pressure (LVPmin). Transient occlusion of the mitral orifice in open chest dogs decreased minimal diastolic LV pressure below zero in >80% of runs, suggesting LV suction plays an important role in diastolic filling.

synapsesocial.com/papers/6a0d442488250cfcc2a4d8bb https://doi.org/10.1253/jcj.46.124

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Left ventricular diastolic suction as a mechanism of ventricular filling.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Left ventricular diastolic suction as a mechanism of ventricular filling.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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