Key result
Long-term antidepressant treatment in panic disorder linked to higher PWV and AIx versus healthy controls.
Why the study?
Do patients with panic disorder have increased arterial stiffness parameters compared to healthy controls?
Case-Control (n=50)
Single-blind
No
Do patients with panic disorder have increased arterial stiffness parameters compared to healthy controls?
p-value: p=0.001
Patients with panic disorder exhibit increased arterial stiffness that correlates with anxiety and depression scores, suggesting a potential mechanism for their increased cardiovascular risk.
May signal heightened CV risk in panic disorder; leaves open whether disorder or antidepressants drive stiffness.
BACKGROUND: The relationship between mental stress and cardiovascular disease has been shown in several studies. Panic disorder (PD) is also associated with cardiovascular disease due to increased risk of myocardial infarction. The aim of this study is to evaluate the association between arterial stiffness parameters and depression/anxiety scores in patients with PD. METHODS: The study population consisted of 25 patients with PD and 25 age-sex-matched healthy controls. Depression and anxiety levels were evaluated by Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI), respectively. Determination of arterial stiffness parameters was conducted using a Mobil-O-Graph arteriograph system that detected signals from the brachial artery. RESULTS: While baseline characteristics were similar between two groups, BDI and BAI scores were significantly higher in patients with PD (p < 0.005). The pulse wave velocity (PWV) and Augmentation Index (AIx) were also significantly higher in patients with PD (p = 0.001, p = 0.006). There was a moderate correlation between PWV and AIx with BAI scores (r = 0.442, p = 0.001, r = 0.441, p = 0.001). AIx was also positively correlated with BDI scores (r = 0.415, p = 0.03). CONCLUSION: We demonstrated a significant relationship between arterial stiffness parameters and anxiety/depression scores in patients with PD who receive antidepressant treatment.
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Yanartaş et al. (2016) conducted a case-control in Panic disorder (n=50). Panic disorder (with long-term SSRI treatment) vs. Healthy controls was evaluated on Pulse wave velocity (PWV) (p=0.001). Patients with panic disorder receiving long-term antidepressant treatment had significantly higher pulse wave velocity (p=0.001) and Augmentation Index (p=0.006) compared to healthy controls.
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