Key result
The Ku70/80 heterodimer, increased sixfold in failing human hearts, interacts with YY1 to synergistically repress the alpha myosin heavy-chain promoter.
The Ku protein complex (Ku70/80) interacts with YY1 to repress alpha myosin heavy-chain gene expression, suggesting a molecular mechanism for reduced contractility in human heart failure.
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Hypothesis-generating for contractile impairment in HF; leaves open whether Ku70/80-YY1 targeting alters progression.
Sucharov et al. (2004) studied Heart failure. Ku70/80 and YY1 overexpression was evaluated on alphaMyHC promoter activity and mRNA expression. The Ku70/80 heterodimer, increased sixfold in failing human hearts, interacts with YY1 to synergistically repress the alpha myosin heavy-chain promoter.
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