What is the clinical evidence from this study?

Population: Cardiac chamber-specific gene expression. Intervention: Irx4, VDR, and RXR alpha interaction. Primary outcome: slow MyHC3 gene expression.

August 1, 2001Journal of Biological ChemistryOpen Access

Irx4 Forms an Inhibitory Complex with the Vitamin D and Retinoic X Receptors to Regulate Cardiac Chamber-specific slow MyHC3Expression

View Full Paper

Ask AI

Bookmark

Key result

Irx4 interacts with the RXR alpha component of the VDR/RXR alpha heterodimer to form an inhibitory complex that represses slow MyHC3 gene expression in the ventricular chambers.

Population

Preclinical models studying chick/quail homologs of slow MyHC3

Design

Preclinical

Authors

GWGang Feng WangStanford University WNWilliam NikovitsStanford University ZBZheng‐Zheng BaoCrown College

Discussion

Member takes

Implication

May refine chamber-specific gene regulation models; leaves open translational relevance to human cardiogenesis or disease.

Structured PICO

Population

Preclinical models (ventricular cardiomyocytes, two-hybrid and co-immunoprecipitation assays) studying chick/quail homologs of slow MyHC3

Intervention

Irx4 protein

Outcome

Repression of slow MyHC3 gene expression in ventricular cardiomyocytessurrogate

The study identifies a novel molecular mechanism where Irx4, VDR, and RXR alpha form an inhibitory complex to restrict slow MyHC3 expression to the atrial chambers during heart development.

Cite This Study

Wang et al. (2001) studied Cardiac chamber-specific gene expression. Irx4, VDR, and RXR alpha interaction was evaluated on slow MyHC3 gene expression. Irx4 interacts with the RXR alpha component of the VDR/RXR alpha heterodimer to form an inhibitory complex that represses slow MyHC3 gene expression in the ventricular chambers.

synapsesocial.com/papers/6a0d51bf88250cfcc2a4df24 https://doi.org/10.1074/jbc.m103716200

View Full Paper

Ask AI

Bookmark

Irx4 Forms an Inhibitory Complex with the Vitamin D and Retinoic X Receptors to Regulate Cardiac Chamber-specific slow MyHC3Expression

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Irx4 Forms an Inhibitory Complex with the Vitamin D and Retinoic X Receptors to Regulate Cardiac Chamber-specific slow MyHC3Expression

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider