Key result
An atrial regulatory domain (ARD1) acts as an atrial cell-specific enhancer of the slow MyHC 3 gene by inhibiting its expression in ventricular cardiocytes via a vitamin D3 receptor-like element.
Population
Primary cardiocyte cultures and developing chick embryos
Comparison
Investigation of the 5′ upstream region of the… vs Ventricular cardiocytes
Design
Preclinical
Authors
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Should not yet influence clinical practice; leaves open ARD1 conservation and function in human atrial development.
This study identifies ARD1 and a specific 40-base pair vitamin D3 receptor-like element as the first atrial cell-specific enhancer that restricts slow MyHC 3 gene expression to the atria during embryonic heart development.
Wang et al. (1996) studied Embryonic heart development. Atrial regulatory domain (ARD1) was evaluated on Atrial cell-specific expression of slow MyHC 3 gene. An atrial regulatory domain (ARD1) acts as an atrial cell-specific enhancer of the slow MyHC 3 gene by inhibiting its expression in ventricular cardiocytes via a vitamin D3 receptor-like element.
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