October 1, 1998Molecular and Cellular BiologyOpen Access

A Positive GATA Element and a Negative Vitamin D Receptor-Like Element Control Atrial Chamber-Specific Expression of a Slow Myosin Heavy-Chain Gene during Cardiac Morphogenesis

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Population

Quail embryos (tubular heart, atrial and ventricular cardiomyocytes) and fibroblasts

Design

Preclinical

Authors

GWGang Feng WangStanford University WNWilliam NikovitsStanford University MSMark D. SchleinitzBrown University

Discussion

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Implication

Findings remain preclinical and should not change practice; extends molecular understanding of atrial chamber specification in embryonic models.

Structured PICO

Population

Quail embryos (tubular heart, atrial and ventricular cardiomyocytes) and fibroblasts

Intervention

Expression of GATA-4, Nkx2-5, or myocyte enhancer factor 2C; overexpression of vitamin D receptor (VDR)

Outcome

Expression of slow myosin heavy chain (MyHC) 3 gene and heterologous reporter genesurrogate

This study identifies the specific cis elements (GATA and VDR-like motifs) responsible for the spatial restriction of slow MyHC 3 gene expression to the atrial chamber during embryonic heart development.

Cite This Study

Wang et al. (1998) studied this question.

synapsesocial.com/papers/6a8337289080d9133c4ce2cb https://doi.org/10.1128/mcb.18.10.6023

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Implication

Findings remain preclinical and should not change practice; extends molecular understanding of atrial chamber specification in embryonic models.

A Positive GATA Element and a Negative Vitamin D Receptor-Like Element Control Atrial Chamber-Specific Expression of a Slow Myosin Heavy-Chain Gene during Cardiac Morphogenesis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A Positive GATA Element and a Negative Vitamin D Receptor-Like Element Control Atrial Chamber-Specific Expression of a Slow Myosin Heavy-Chain Gene during Cardiac Morphogenesis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider